All Safe Codes & Locations in RE9 (Normal + Insanity)
Looking for every RE9 safe code in Resident Evil 9: Requiem? There are 5 safes hidden across the game's four main areas, and each one contains valuable weapons, upgrades, or crafting resources you do not want to miss. This guide lists all RE9 safe combinations for both Normal and Insanity difficulty, along with the exact location of each safe and where to find the clue for its code. Whether you are playing through for the first time or tackling Insanity mode, these RE9 safe codes will help you unlock every reward.
What Are Safes in RE9?
Safes in Resident Evil 9: Requiem are locked containers scattered throughout the game world that require a specific three-digit combination to open. Each safe contains high-value loot such as weapon attachments, rare crafting materials, or key items needed for full completion. Finding all RE9 safe codes is essential for completionists and recommended for any player who wants to maximize their loadout.
Importantly, safe codes change between Normal and Insanity difficulty. If you are on your second playthrough in Insanity mode, the codes you used previously will not work. This guide covers both sets of RE9 safe combinations so you are prepared regardless of your difficulty setting.
📝Safe Codes Are Fixed Per Difficulty
Unlike some puzzles in RE9, safe codes are not randomized between playthroughs on the same difficulty. Normal mode codes are always the same, and Insanity mode codes are always the same. You can refer back to this guide on any playthrough.
How to Open All 5 Safes in RE9
Below you will find every RE9 safe code organized by area. Each entry includes the safe location, the code for Normal and Insanity difficulty, what you receive, and where to find the in-game clue.
Safe 1: Wrenwood Hotel Manager's Office
The first safe you encounter is located in the Manager's Office on the second floor of the Wrenwood Hotel. You can access this room after obtaining the Manager's Key during the Wrenwood Hotel chapter. The safe is behind the painting on the east wall.
In-game clue: Check the guest registration book on the front desk. The three circled room numbers correspond to the combination digits.
Safe 2: Rhodes Hill Church Basement
The second safe is found in the basement of the abandoned church in Rhodes Hill. After completing the cemetery puzzle, descend into the basement through the trapdoor near the altar. The safe is sitting on a metal shelf in the southeast corner of the storage room.
In-game clue: Look at the stained glass window dates etched on the brass plaque to the left of the safe. The Roman numerals translate to the code.
Safe 3: Raccoon City Police Station Evidence Room
This safe is located in the Evidence Room of the Raccoon City Police Department, accessible during the RPD & Orphanage chapter. The safe is mounted on the wall behind the evidence shelves. You need to move the shelving unit first by interacting with the lever on the side.
In-game clue: The wanted poster on the notice board outside the Evidence Room has three suspect ID numbers. The last digit of each number forms the RE9 safe code.
Safe 4: Raccoon City Underground Tunnels
The fourth safe is hidden in the underground tunnel system beneath Raccoon City. After the sewer section, follow the side passage to the northeast until you reach the maintenance room. The safe is on the workbench in the back corner, partially obscured by pipes.
In-game clue: Examine the maintenance log pinned to the corkboard next to the safe. The entry dates (month numbers only) spell out the RE9 safe combination for this location.
Safe 5: ARK Research Lab Director's Office
The final safe in RE9 is located in the Director's Office of the ARK Research Lab, the game's last major area. This is the most rewarding safe in the game and is easy to miss during the story's climactic sequence. The safe is built into the director's desk on the left side.
In-game clue: Access the director's computer terminal and read the email titled "Security Update." The new access code mentioned in the email is the RE9 safe code.
Complete RE9 Safe Codes Quick Reference
Use this table for fast lookup of all RE9 safe codes in one place. Bookmark this page so you can reference it during your playthrough.
| # | Location | Normal Code | Insanity Code | Reward |
|---|---|---|---|---|
| 1 | Wrenwood Hotel | 9-1-8 | 3-6-1 | Extended Handgun Magazine |
| 2 | Rhodes Hill Church | 4-7-2 | 8-1-5 | Shotgun Stock |
| 3 | RPD Evidence Room | 2-0-3 | 7-4-9 | Magnum Ammo + First Aid Spray |
| 4 | Underground Tunnels | 6-5-1 | 2-9-3 | Gunpowder + Tactical Knife |
| 5 | ARK Research Lab | 7-3-6 | 5-0-8 | Infinite Knife |
Why You Should Open Every Safe in RE9
Opening all 5 safes in RE9 is important for several reasons. First, the rewards significantly improve your combat effectiveness. The Extended Handgun Magazine and Shotgun Stock from the first two safes give you a meaningful advantage for the rest of the game. Second, the Infinite Knife from the final safe in the ARK Research Lab is one of the most valuable unlockables in RE9, making subsequent playthroughs significantly easier by removing knife durability concerns entirely.
For completionists, opening every safe also contributes to the "Master Locksmith" achievement and counts toward your overall completion percentage. If you are tracking all collectibles and puzzle completions, these RE9 safe codes are essential.
💡Do Not Miss Any Safe
Some safes become inaccessible after certain story events. The Wrenwood Hotel and Rhodes Hill safes should be opened before completing those chapters. The RPD and Underground safes remain accessible until the ARK section. Open each safe as soon as you find it to avoid missing out.
Frequently Asked Questions
Are RE9 safe codes randomized?
No, RE9 safe codes are fixed for each difficulty level. Normal mode always uses the same set of codes, and Insanity mode always uses its own separate set. The RE9 safe combinations listed in this guide work on every playthrough of the same difficulty.
Can I open safes on any difficulty?
Yes, all 5 safes appear on every difficulty mode from Casual through Insanity. The only difference is that Normal/Standard difficulties share one set of codes, while Insanity mode uses different codes. Casual and Standard modes use the Normal codes listed above.
What happens if I miss a safe?
If you miss a safe before a point of no return, you will need to open it on a subsequent playthrough. Safe rewards do not carry over between playthroughs, so you must open them each time. Check our Care Center walkthrough for tips on making sure you explore each area thoroughly.
Where can I find more puzzle solutions?
This guide covers only safe codes. For other RE9 puzzles, visit our puzzle solutions hub which includes guides for puzzle boxes, the organless corpse puzzle, the blood specimen analyzer, and every other puzzle in Resident Evil 9: Requiem.
With all 5 RE9 safe codes in hand, you are ready to claim every reward the game has to offer. Make sure to open each safe as you progress through the story, starting with the Wrenwood Hotel chapter. For more puzzle help, browse the full puzzle solutions index or continue with the RPD & Orphanage walkthrough.